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Nephrotoxicity interaction of drugs with membranes systems mitochondria-lysosomes

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Published by Masson Pub. USA in New York .
Written in English


  • Nephrotoxicology -- Congresses.,
  • Renal pharmacology -- Congresses.,
  • Mitochondrial membranes -- Effect of drugs on -- Congresses.,
  • Lysosomes -- Effect of drugs on -- Congresses.,
  • Drugs -- Toxicology -- Congresses.

Book details:

Edition Notes

Statementedited by Jean-Paul Fillastre.
SeriesPublications de l"Université de Rouen
ContributionsFillastre, Jean-Paul., Université de Rouen. Groupe de physiopathologie tissulaire.
LC ClassificationsRC904 .N46
The Physical Object
Pagination332 p., [4] leaves of plates :
Number of Pages332
ID Numbers
Open LibraryOL4442444M
ISBN 100893520322
LC Control Number79104003

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With the advent of effective cytotoxic chemotherapy, attention has turned to the side effects of these widely used agents (Table ). These side effects include tumor lysis syndrome, paraneoplastic glomerulonephritis, obstructive uropathy, and nephrotoxicity with renal failure and electrolyte disturbances. These are more common in the geriatric population secondary to polypharmacy/drug Author: Christopher J. Logothetis, Vasily Assikis, Jose E. Sarriera. nephrogenic diabetes insipidus and nephrotoxicity in animal models Department of Pharmaceutical Sciences JJTU Page 8 Chapter-1 INTRODUCTION Nephrotoxicity: The kidneys are paired and bean shaped organs, located on either sides of the vertebral column. The File Size: KB. nephrotoxicity: (nef'rō-tok-sis'i-tē), The quality or state of being toxic to kidney cells. Nephrotoxicity is the principal adverse event associated with systemic administration of cidofovir. 94,95 Cidofovir concentrates in renal cells in amounts times greater than in other tissues, producing severe nephrotoxicity involving the proximal convoluted tubule when concomitant hydration and administration of probenecid are not employed.

Patients at highest risk of drug-induced nephrotoxicity are those with one or more of the following: age older than 60 years, baseline renal insufficiency (e.g., GFR Cited by:   Nephrotoxicity can be defined as the adverse effect of substances on renal function (Perazella, ).These substances can include molds and fungi, cancer therapeutics such as cisplatin, antibiotics such as aminoglycosides, metals such as mercury, arsenic and lead, and drugs of Cited by: Define nephrotoxicity. nephrotoxicity synonyms, nephrotoxicity pronunciation, nephrotoxicity translation, English dictionary definition of nephrotoxicity. n med the quality of being nephrotoxic. Nephrotoxicity - definition of nephrotoxicity by The Free Dictionary. [19] [20] [21] The number of patients developing nephrotoxicity increases with duration of therapy reaching 50% if the therapy is continued for 14 days or more. 22 Renal damage caused by.

There has been a growing awareness that nephrotoxicity represents a key factor in human nephropathies, where, irrespective of the causative agent, only a few clinical end-effects are diagnosed. Thus nephropathies are generally classified as acute or chronic renal failure, malignancies or. Aminoglycoside (AG) nephrotoxicity is a well-known occurrence. However, 50 years after the discovery of the first AG (streptomycin), nephrotoxicity is still very difficult to predict and avoid ().To date, no model has completely described the pharmacodynamic behavior of AG nephrotoxicity, even though the mechanism of this toxicity has been widely studied (4, 7, 15, 27). Drug-induced nephrotoxicity is a renal dysfunction that occurs as a result of exposure to nephrotoxic drugs. It is a common problem in certain clinical situations such as underlying renal dysfunction, cardiovascular disease, diabetes, and sepsis. Drugs can cause mild to moderate nephrotoxic problems such as intrarenal obstruction, interstitial nephritis, nephrotic syndrome, acid-base and fluid Cited by: 1. The kidneys normally receive 20% of the cardiac output. Drugs are filtered and/or secreted and then progressively concentrated in the urine. Therefore, these organs are especially vulnerable to the toxic effects of many drugs, including chemotherapy toxicity is often a dose-limiting adverse effect of chemotherapy. Chemotherapy agents can affect the microvasculature, the glomerulus.